Why Axsome Therapeutics Stock Jumped Over 20% in April

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Howard Smith, The Motley Fool

Sat, May 2, 2026 astatine 10:07 AM CDT 3 min read

Axsome Therapeutics (NASDAQ: AXSM) has been increasing income rapidly with its Auvelity antidepressant. The biopharmaceutical institution focuses connected processing therapies for cardinal tense strategy (CNS) disorders.

Auvelity, launched successful precocious 2022, has been approved to dainty large depressive upset (MDD) successful adults, and income person been increasing quickly. That's lone portion of the crushed Axsome banal soared past month. Shares jumped 22.9%, according to information provided by S&P Global Market Intelligence.

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image of encephalon  successful  purple with pinkish  streak, representing Alzheimer's disease.

Image source: Getty Images.

5 cardinal caller reasons to bargain

Auvelity helped Axsome turn income by 66% past year. Auvelity income grew adjacent faster, accounting for astir 80% of the company's revenue. Its different drugs, Sunosi (to amended wakefulness successful adults who acquisition excessive daytime sleepiness associated with narcolepsy) and Symbravo (for migraine relief), marque up the balance.

But the stock's large determination successful April came for a antithetic reason. Auvelity received support from the U.S. Food and Drug Administration (FDA) for the attraction of agitation associated with dementia that tin travel with Alzheimer's disease.

It's 1 of the large problems associated with Alzheimer's. According to the company, of the implicit 7 cardinal Americans surviving with Alzheimer's disease, much than 5 cardinal are dealing with agitation from Alzheimer's, with lone 1 antecedently approved treatment. With its existing web of income representatives and insurance-sector relationships successful place, Axsome volition beryllium acceptable to motorboat the cause for the caller exertion successful astir 1 month.

Price people boosts

The caller support has analysts raising terms targets for Axsome stock. Needham & Company already recommended investors bargain the stock, but has present raised the terms people from $225 to $255 per share. Similarly, TD Cowen boosted its people stock terms to $255 from $215, according to reports. That terms level represents a 23.5% summation from past week's closing price.

One large crushed for the optimism surrounding the caller support is that Auvelity volition beryllium the archetypal medicine approved for the information that is not an antipsychotic. Rexulti, discovered by Otsuka Pharmaceutical and co-developed by biopharmaceutical institution Lundbeck, is the lone different attraction FDA-approved for Alzheimer's agitation. But it carries a achromatic container informing arsenic an antipsychotic. Auvelity won't transportation that informing of an accrued hazard of decease successful aged patients with dementia-related psychosis.

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