Ozempic users may be making a major weight-loss mistake, new study suggests

Among those taking GLP-1 medications for value loss, workout rates are decreasing, according to caller research.

The study, acceptable to beryllium presented astatine ENDO 2026 (the Endocrine Society's yearly meeting) successful Chicago this week, recovered that adults with obesity who mislaid value with a GLP-1, specified arsenic Ozempic oregon Wegovy, "significantly reduced" their carnal activity.

In an Endocrine Society property release, survey pb Sajana Maharjan, MD, of HSHS St. John's Hospital successful Springfield, Illinois, noted that GLP-1 drugs similar semaglutide, liraglutide, dulaglutide and tirzepatide trim some abdominous and thin musculus mass.

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This means carnal enactment is "essential for preserving spot and semipermanent health," she said.

The study, reportedly the archetypal of its kind, considered information from a National Institutes of Health probe programme that linked subordinate records with fittingness tracker activity.

Researchers analyzed information from 753 radical with obesity who initiated a GLP-1 medication. The cohort was mostly female, astatine a mean property of 52.7 years.

Among participants, the mean fig of steps decreased from 5,047 to 4,487 per day. (iStock)

Comparing enactment successful participants earlier and aft opening treatment, the mean fig of steps decreased from 5,047 to 4,487 per day. Moderate-to-vigorous carnal enactment fell from 28 to 22 minutes per day, the survey found.

The largest declines were observed successful men and successful those with associated oregon musculus pain. Other factors similar age, bosom nonaccomplishment oregon anterior changeable did not alteration results.

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Although galore radical mightiness presume that losing value with these medications would pb to accrued carnal activity, the survey recovered nary grounds that it did, according to Maharjan.

"The findings successful our survey reenforce that workout cannot beryllium optional for radical taking these medications," helium said. "People request targeted interventions that promote carnal enactment alongside medicine for obesity."

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The survey was retrospective and observational, meaning it could lone show an association, not a nonstop cause. The participants were besides mostly middle-aged women, which could bounds the scope of who is astir impacted, the researchers noted.

Other factors that were not measured see workout habits earlier starting treatment, information levels and guidance from a physician.

Although galore radical mightiness presume that losing value with these medications would pb to accrued carnal activity, the survey recovered nary grounds that it did, according to the researcher. (iStock)

Dr. Peter Balazs MD, a hormone and weight-loss specializer practicing successful New York and New Jersey, echoed successful an interrogation with Fox News Digital that value nonaccomplishment does not automatically pb to accrued mobility oregon greater information to exercise.

"In fact, being successful a calorie shortage tin origin the assemblage to conserve energy, resulting successful a little metabolic rate," helium said.

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"Additionally, broadside effects of weight-loss medications, specified arsenic nausea, fatigue oregon gastrointestinal discomfort, whitethorn further trim a person's quality oregon tendency to beryllium physically active," the adept added.

For GLP-1 users, Balazs stressed that workout "is not optional." Patients indispensable incorporated absorption grooming and regular regular movement, similar walking, into their regular to "preserve thin musculus mass, support metabolic wellness and enactment semipermanent value management," helium advised.

Exercise supports bony and associated wellness and enhances cardiovascular fitness, the researcher said. (iStock)

"Exercise plays a captious relation during value loss," Balazs said. "Without capable carnal activity, a important information of value nonaccomplishment whitethorn travel from musculus alternatively than fat."

The adept noted that determination is not a one-size-fits-all approach, arsenic the timing, strength and benignant of workout should beryllium individualized based connected a person’s fittingness level, wellness presumption and assemblage composition.

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"This is peculiarly important for patients with a precocious BMI who whitethorn person mobility limitations oregon little baseline fittingness levels," Balazs said. "It's important to see wounded risk, semipermanent adherence and the imaginable for aboriginal burnout."

Contrasting views

Board-certified internist and longevity adept Dr. Amanda Kahn said she disagrees with this study’s conclusions, arsenic they bash not bespeak what she is seeing successful her ain objective practice.

"Weight nonaccomplishment often serves arsenic the impetus that motivates patients to go much physically progressive and much engaged successful their wide health," the New York-based adept told Fox News Digital.

Successful attraction requires regular follow-up, monitoring of macromolecule intake, monthly value checks, quarterly assemblage creation scans and regular laboratory testing, an adept advised. (iStock)

"The occurrence of GLP-1 therapy is straight tied to the expertise of the provider," she went on. "When these medications are prescribed thoughtfully – with attraction to nutrition, absorption training, assemblage creation and laboratory monitoring – they tin assistance patients suffer value portion becoming healthier, stronger and much motivated to exercise."

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Kahn, a peptide prescriber, does not urge simply prescribing a GLP-1 medicine and allowing the diligent to "self-manage."

"In my practice, if a diligent is incapable to exercise, is not gathering macromolecule goals oregon shows concerning musculus nonaccomplishment connected assemblage creation analysis, I volition often clasp oregon set the medicine – due to the fact that preserving strength, relation and metabolic wellness is conscionable arsenic important arsenic value loss," she said.

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If a GLP-1 diligent becomes excessively fatigued to exercise, develops nutritional deficiencies oregon loses excessive musculus mass, Kahn warned that this reflects a "monitoring problem" alternatively than a medicine problem, arsenic these medications "require adjacent objective oversight."